HORDB

ID: hor005577
Uniprot ID: P58990
Protein name: Conophysin-R
Gene name: NA
Organism: Conus radiatus (Rayed cone)
Family: Vasopressin/oxytocin family
Source: animal
Expression: Expressed by the venom duct.
Disease: NA
Comments: NA
Taxonomy: Phasmoconus (subgenus), Conus (genus), Conidae (family), Conoidea (superfamily), Neogastropoda (order), Caenogastropoda (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005185 neurohypophyseal hormone activity; GO:0090729 toxin activity
GO BP: GO:0007165 signal transduction; GO:0035821 modulation of process of another organism
GO CC: GO:0005576 extracellular region

Sequence: HPTKPCMYCSFGQCVGPHICCGPTGCEMGTAEANMCSEEDEDPIPCQVFGSDCALNNPDNIHGHCVADGICCVDDTCTTHLGCL
Length: 84
Propeptide: HPTKPCMYCSFGQCVGPHICCGPTGCEMGTAEANMCSEEDEDPIPCQVFGSDCALNNPDNIHGHCVADGICCVDDTCTTHLGCL
Signal peptide: NA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Targets vasopressin-oxytocin related receptors (By similarity). No effect observed when injected into goldfish or into mice.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-P04204-F1.pdb

hor005577_AF2.pdb

hor005577_ESM.pdb

Mass:	1030566	Formula:	C359H549N101O125S17
Absent amino acids:	RW	Common amino acids:	C
pI:	4.02	Basic residues:	6
Polar residues:	37	Hydrophobic residues:	17
Hydrophobicity:	-7.02	Boman Index:	-9011
Half-Life:	3.5 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	51.07
Instability Index:	2557.38	Extinction Coefficient cystines:	2365
Absorbance 280nm:	28.49

PubMed ID: 12076643
Title: Conophysin-R, a Conus radiatus venom peptide belonging to the neurophysin family.